Monday, 23 November 2015

Researching the Cortisol Awakening Response, here are the latest published Consensus Guidelines

Assessment of the cortisol awakening response: Expert consensus guidelines.

Stalder T1, Kirschbaum C2, Kudielka BM3, Adam EK4, Pruessner JC5, Wüst S3, Dockray S6, Smyth N7, Evans P7, Hellhammer DH8, Miller R2, Wetherell MA9, Lupien SJ10, Clow A7.

Author information
1. Department of Psychology, TU Dresden, Dresden, Germany. Electronic address:
2. Department of Psychology, TU Dresden, Dresden, Germany.
3. Department of Psychology, University of Regensburg, Regensburg, Germany.
4. School of Education and Social Policy, Northwestern University, Evanston, USA.
5. Department of Psychiatry, McGill University, Montreal, Canada.
6. School of Applied Psychology, University College Cork, Cork, Ireland.
7. Department of Psychology, University of Westminster, London, UK.
8. Department of Psychology, Trier University, Trier, Germany.
9. Department of Psychology, Northumbria University, Newcastle, UK.
10.Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada.

The cortisol awakening response (CAR), the marked increase in cortisol secretion over the first 30-45min after morning awakening, has been related to a wide range of psychosocial, physical and mental health parameters, making it a key variable for psychoneuroendocrinological research. The CAR is typically assessed from self-collection of saliva samples within the domestic setting. While this confers ecological validity, it lacks direct researcher oversight which can be problematic as the validity of CAR measurement critically relies on participants closely following a timed sampling schedule, beginning with the moment of awakening. Researchers assessing the CAR thus need to take important steps to maximize and monitor saliva sampling accuracy as well as consider a range of other relevant methodological factors. To promote best practice of future research in this field, the International Society of Psychoneuroendocrinology initiated an expert panel charged with (i) summarizing relevant evidence and collective experience on methodological factors affecting CAR assessment and (ii) formulating clear consensus guidelines for future research. The present report summarizes the results of this undertaking. Consensus guidelines are presented on central aspects of CAR assessment, including objective control of sampling accuracy/adherence, participant instructions, covariate accounting, sampling protocols, quantification strategies as well as reporting and interpreting of CAR data. Meeting these methodological standards in future research will create more powerful research designs, thus yielding more reliable and reproducible results and helping to further advance understanding in this evolving field of research.

Monday, 16 November 2015

Experts in Salivary Bioscience, The Laboratory of Social Cognitive Neuroscience (LabNSC), at the University of Valencia, Spain

Featured here another Institution from the Salimetrics Saliva Research Community. Our intention is  to encourage collaboration between Universities and we have made it possible for you to communicate directly 

In recent decades, research in the area of Neurosciences has made startling discoveries that have transformed and improved our understanding about brain function. This has contributed to the development of new treatments and therapies for several neurological and mental disorders. 

The Laboratory of Social Cognitive Neuroscience (LabNSC), at the University of Valencia, is part of the Department of Psychobiology and IDOCAL, Faculty of Psychology. The LabNSC has developed, since its inception, research focused on studying the biological basis of animal and human response to social interactions, especially stress. Specifically, we are interested in the psychobiological mechanisms involved when we are faced with a stressful situation and its effects on cognitive and affective functions.

Research conducted in the laboratory uses an integrative approach based on the convergence of multiple methodologies of study in humans, allowing understanding of the effects of stress on the brain, and consequently in behavior.
In human studies the LabNSC uses comprehensive neuropsychological and electrophysiological evaluations, and neuroendocrine response analysis, target population both young and old men and women. 

Link to Salimetrics Research Tools

Laboratory of Social Cognitive Neuroscience (LabNSC),
 University of Valencia
Av. Blasco Ibañez nº21
46016 - Valencia (Spain)
Telephone: +34 96.386.42.97

Monday, 9 November 2015

Salimetrics delighted to add a further Centre of Excellence: University of Nebraska Lincoln (UNL) Salivary Bioscience Laboratory (SBL)

Salimetrics is proud to support the University of Nebraska Lincoln Salivary Bioscience Laboratory (UNL SBL), now a Salimetrics COE lab offering saliva assay services, sample storage, training in saliva collection, and consultation on research design, IRB protocols, and grant writing for salivary bioscience researchers. The UNL SBL seeks to collaborate with researchers from a variety of academic disciplines, including the social, behavioral, educational, and health sciences, in their pursuits to incorporate salivary biomarkers into scholarly work, and in partnership with the Center for Brain, Biology and Behavior (CB3) and Nebraska Athletic Performance Laboratory (NAPL), the UNL SBL also explores the role of salivary biomarkers in understanding the performance of collegiate student-athletes.

Visit the UNL SBL online to connect, view services, or request more information: 

The mission of the UNL Salivary Bioscience Laboratory (SBL) is to facilitate the integration of salivary biomarkers into academic research and bring salivary bioscience to elite athletes.

Salivary hormones response to preparation and pre-competitive training of world-class level athletes, open article

Salivary hormones response to preparation and pre-competitive training of world-class level athletes

Gaël Guilhem (1*)  Christine Hanon (1) Nicolas Gendreau (1) Dominique Bonneau (2) Arnaud Guével (3) and Mounir Chennaoui (2)
1. Research Department, French National Institute of Sport (INSEP), France
2. French Armed Forces Biomedical Research Institute (IRBA), Neurosciences and Operational Constraints Department, Paris Descartes University, France
3. University of Nantes, France

Link to Open Access Full Paper

This study aimed to compare the response of salivary hormones of track and field athletes induced by preparation and pre-competitive training periods in an attempt to comment on the physiological effects consistent with the responses of each of the proteins measured. Salivary testosterone, cortisol, alpha-amylase, immunoglobulin A, chromogranin A, blood creatine kinase activity and profile of mood state were assessed at rest in 24 world-class level athletes during preparation (3 times in 3 months) and pre-competitive (5 times in 5 weeks) training periods. Total mood disturbance and fatigue perception were reduced, while immunoglobulin A (+61%) and creatine kinase activity (+43%) increased, and chromogranin A decreased (-27%) during pre-competitive compared to preparation period. A significant increase in salivary testosterone (+9 to +15%) and a decrease in testosterone/cortisol ratio were associated with a progressive reduction in training load during pre-competitive period (P < 0.05). None of the psycho-physiological parameters were significantly correlated to training load during the pre-competitive period. Results showed a lower adrenocortical response and autonomic activity, and an improvement of immunity status, in response to the reduction in training load and fatigue, without significant correlations of salivary hormones with training load. Our findings suggest that saliva composition is sensitive to training contents (season period) but could not be related to workload resulting from track and field athletics training.
Keywords: Alpha-Amylase, Immunoglobulin A, Chromogranin A, Creatine Kinase, Athletics Training

Citation: Guilhem G, Hanon C, Gendreau N, Bonneau D, Guével A and Chennaoui M (2015). Salivary hormones response to preparation and pre-competitive training of world-class level athletes. Front. Physiol. 6:333. doi: 10.3389/fphys.2015.00333

Received: 21 Sep 2015; Accepted: 02 Nov 2015.
Edited by:
Vincent Pialoux, University Lyon 1, France

Link to Salimetrics Salivary Assays